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Indication

What is TARPEYO?

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

RESOURCES AND FAQs

Resources

Taking steps early can make a real difference to help preserve kidney function. Access these helpful tools and downloadable resources to help you take the next step along your IgA Nephropathy (IgAN) journey with TARPEYO.

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TARPEYO Touchpoints®
Enrollment Form

To get started on TARPEYO, you and your 
doctor will fill out this enrollment form.

Learn more about TARPEYO Touchpoints
DOWNLOAD FORM
tarpeyo patient brochure

TARPEYO Patient Brochure

Get the facts about IgAN and learn how TARPEYO 
can help you preserve kidney function.

Learn more about IgAN
DOWNLOAD BROCHURE (ENGLISH) DOWNLOAD BROCHURE (ESPAÑOL)
TARPEYO Patient Ambassador Brochure image

TARPEYO Patient
Ambassador Brochure

Meet real people who took 
charge with TARPEYO.

Hear patient stories
DOWNLOAD BROCHURE
Doctor Discussion Guide

TARPEYO
Doctor Discussion Guide

Download this helpful guide to bring with you to 
your next appointment.

Learn more about starting TARPEYO
DOWNLOAD GUIDE
Woman in a blue sweatshirt smiling while holding a pen.
Woman in a blue sweatshirt smiling while holding a pen.

Yelena, actual TARPEYO patient
Yelena was compensated for her time

REAL PEOPLE WHO TOOK CHARGE WITH TARPEYO

“I’m already through 9 months of TARPEYO, and 
I’m feeling better. I got the support and 
resources I needed for my IgAN journey.” 
-Yelena

hear patient stories

IgA Nephropathy (IgAN) Frequently Asked Questions

IgAN is a rare, progressive immune-driven disease that is thought to start in the gut—with Gd-IgA1, or galactose-deficient IgA1 antibody, setting off a chain reaction that eventually damages the kidneys.

In people with IgAN, Gd-IgA1 combines with other antibodies to form IgA1 clusters. These IgA1 clusters can build up in the kidneys, leading to damage and a decline in kidney function. While many people with IgAN may not feel symptoms, kidney damage can still be occurring over time.

Learn more about IgAN

One of the main, underlying causes of IgAN is thought to be the galactose-deficient IgA1 antibody (Gd-IgA1), which is most often produced in the gut. Not all treatments for IgAN are designed to address Gd-IgA1 in the gut.

Explore the gut-kidney connection in IgAN

Although IgAN is often asymptomatic in early stages, you may experience the following:

  • Lower back pain
  • Blood in the urine
  • Foamy urine due to excess protein
  • Swelling in feet, ankles, or legs

Uncover the gut-kidney connection in IgAN

  • A diagnosis of IgAN is confirmed with a kidney biopsy
  • A kidney biopsy is a procedure that involves taking a small piece of kidney tissue for examination
  • A biopsy may reveal IgA deposits in the kidney filters
  • The biopsy can also show how much kidney damage has already occurred
  • By the time IgAN is diagnosed, some kidney damage may have already occurred

Learn more about IgAN

TARPEYO Frequently Asked Questions

TARPEYO is an FDA-approved medicine that targets a source of IgA Nephropathy in the gut.

Learn more about TARPEYO

Developed specifically for people with IgAN, TARPEYO was designed intelligently to deliver the medicine budesonide directly in the gut where it is thought to work, and limit exposure in areas where it is not.*

*It has not been established to what extent the efficacy of TARPEYO is from local effects (in the gut) vs systemic effects (in circulation).

Discover the technology of TARPEYO

Unlike traditional steroids that impact your entire body, TARPEYO is designed to work locally in the gut to help lower Gd-IgA1,† thought to be an underlying cause of IgAN. TARPEYO was studied in a 2-year trial and was found to be generally well tolerated.

†It has not been established to what extent the efficacy of TARPEYO is from local effects (in the gut) vs systemic effects (in circulation).

See how TARPEYO may fit into your life

Not exactly. The triple-coated technology of the TARPEYO capsule is designed to deliver medicine to a specific area of the gut, dissolving where Gd-IgA1 is most often produced. The active ingredient in TARPEYO (budesonide) acts locally to reduce inflammation.‡

‡It has not been established to what extent the efficacy of TARPEYO is from local effects (in the gut) vs systemic effects (in circulation).

Discover what makes TARPEYO unique

No. Currently there is no generic version of TARPEYO available in the United States.

Get help starting with TARPEYO

  • Some people may see a slight weight gain while taking TARPEYO. In the clinical trial, median increases were not greater than 2.2 pounds, and those increases in body weight resolved within 3 months of ending treatment.§
  • Some people experienced small changes to blood pressure and/or blood sugar. These changes resolved to pre-treatment levels within 3 months of completing TARPEYO.

§Median body weight increases at 6 months for TARPEYO group.

Learn more about taking TARPEYO

Advocacy Groups

The IgA Nephropathy Foundation’s mission is to be a patient-centric organization focused on finding a cure for IgA Nephropathy. Using the power of the patient community, the foundation is focused on funding research, using patient advocacy to empower patients, and building a network of support.

VISIT WEBSITE browse icon

The National Kidney Foundation is revolutionizing the fight to save lives by eliminating preventable kidney disease, accelerating innovation for the dignity of the patient experience, and dismantling structural inequities in kidney care, dialysis, and transplantation.

VISIT WEBSITE browse icon

NephCure is shaping the future of rare kidney disease by empowering patients to take charge of their health, while leading the revolution in research, new treatments, and care.

VISIT WEBSITE browse icon

The American Kidney Fund works on behalf of the 1 in 7 Americans living with kidney disease, and the millions more at risk, to support people wherever they are in their fight against kidney disease—from prevention through post-transplant living.

VISIT WEBSITE browse icon

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Indication

What is TARPEYO?

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

Important Safety Information

Do not take TARPEYO if you are allergic to budesonide or any of the ingredients in TARPEYO. See the end of the Patient Information for a complete list of ingredients in TARPEYO.

Before taking TARPEYO, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • plan to have surgery
  • have chickenpox or measles or have recently been near anyone with chickenpox or measles
  • have an infection
  • have high blood sugar levels (prediabetes or diabetes)
  • have glaucoma or cataracts
  • have a family history of diabetes or glaucoma
  • have or have had tuberculosis
  • have high blood pressure (hypertension)
  • have decreased bone mineral density (osteoporosis)
  • have stomach ulcers
  • are pregnant or plan to become pregnant. TARPEYO may harm your unborn baby. Talk to your healthcare provider about the possible risk to your unborn baby if you take TARPEYO when you are pregnant
  • are breastfeeding or plan to breastfeed. It is not known if TARPEYO passes into your breast milk or if it will affect your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with TARPEYO

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TARPEYO and other medicines may affect each other causing side effects.

How should I take TARPEYO?

  • Take TARPEYO exactly as your healthcare provider tells you
  • Your healthcare provider will decide how long you should take TARPEYO. Do not stop taking TARPEYO without first talking with your healthcare provider
  • Take your prescribed dose of TARPEYO 1 time each day in the morning, at least 1 hour before a meal
  • Swallow TARPEYO capsules whole. Do not open, chew, crush, or break TARPEYO capsules before swallowing
  • If you miss a dose of TARPEYO, take your prescribed dose at your next scheduled time. Do not take two doses of TARPEYO at the same time
  • If you take too much TARPEYO, call your healthcare provider right away or go to the nearest hospital emergency room

What should I avoid while taking TARPEYO?

Do not eat grapefruit or drink grapefruit juice during your treatment with TARPEYO. Eating grapefruit or drinking grapefruit juice can increase the level of TARPEYO in your blood.

What are the possible side effects of TARPEYO?

TARPEYO may cause serious side effects, including:

  • Effects of having too much corticosteroid medicine in your blood (hypercorticism): Long-time use of TARPEYO can cause you to have signs and symptoms of too much cortisol, a stress hormone in your blood. Tell your healthcare provider if you have any of the following signs and symptoms of hypercorticism: acne, bruise easily, rounding of your face (moon face), ankle swelling, thicker or more hair on your body and face, a fatty pad or hump between your shoulders (buffalo hump), or pink or purple stretch marks on the skin of your abdomen, thighs, breasts, or arms
  • Adrenal suppression: When TARPEYO is taken for a long period of time (chronic use), adrenal suppression can happen. This is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal suppression include tiredness, weakness, nausea and vomiting, and low blood pressure. Tell your healthcare provider if you are under stress or have any symptoms of adrenal suppression during treatment with TARPEYO
  • Risk of immunosuppression: TARPEYO weakens your immune system. Taking medicines that weaken your immune system makes you more likely to get infections. Avoid contact with people who have contagious diseases, such as chickenpox or measles, during treatment with TARPEYO. Tell your healthcare provider right away if you come in contact with anyone who has chickenpox or measles. Consult with your healthcare provider regarding appropriate vaccination scheduling
  • Tell your healthcare provider if you develop any symptoms of infection during treatment with TARPEYO, including fever, feeling tired, chills, aches, pain, and nausea and vomiting

The most common side effects of TARPEYO include:

  • swelling of the lower legs, ankles, and feet
  • high blood pressure
  • muscle spasms
  • acne
  • headache
  • upper respiratory tract infection
  • swelling of the face
  • weight increase
  • indigestion
  • irritation or inflammation of the skin
  • joint pain
  • increased white blood cell count

These are not all the possible side effects of TARPEYO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information.

Indication and Important Safety Information

What is TARPEYO?

TARPEYO is a prescription medicine used to reduce the loss of kidney function in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk for their disease getting worse. It is not known if TARPEYO is safe and effective in children.

Important Safety Information

Do not take TARPEYO if you are allergic to budesonide or any of the ingredients in TARPEYO. See the end of the Patient Information for a complete list of ingredients in TARPEYO.

Before taking TARPEYO, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • plan to have surgery
  • have chickenpox or measles or have recently been near anyone with chickenpox or measles
  • have an infection
  • have high blood sugar levels (prediabetes or diabetes)
  • have glaucoma or cataracts
  • have a family history of diabetes or glaucoma
  • have or have had tuberculosis
  • have high blood pressure (hypertension)
  • have decreased bone mineral density (osteoporosis)
  • have stomach ulcers
  • are pregnant or plan to become pregnant. TARPEYO may harm your unborn baby. Talk to your healthcare provider about the possible risk to your unborn baby if you take TARPEYO when you are pregnant
  • are breastfeeding or plan to breastfeed. It is not known if TARPEYO passes into your breast milk or if it will affect your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with TARPEYO

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TARPEYO and other medicines may affect each other causing side effects.

How should I take TARPEYO?

  • Take TARPEYO exactly as your healthcare provider tells you
  • Your healthcare provider will decide how long you should take TARPEYO. Do not stop taking TARPEYO without first talking with your healthcare provider
  • Take your prescribed dose of TARPEYO 1 time each day in the morning, at least 1 hour before a meal
  • Swallow TARPEYO capsules whole. Do not open, chew, crush, or break TARPEYO capsules before swallowing
  • If you miss a dose of TARPEYO, take your prescribed dose at your next scheduled time. Do not take two doses of TARPEYO at the same time
  • If you take too much TARPEYO, call your healthcare provider right away or go to the nearest hospital emergency room

What should I avoid while taking TARPEYO?

Do not eat grapefruit or drink grapefruit juice during your treatment with TARPEYO. Eating grapefruit or drinking grapefruit juice can increase the level of TARPEYO in your blood.

What are the possible side effects of TARPEYO?

TARPEYO may cause serious side effects, including:

  • Effects of having too much corticosteroid medicine in your blood (hypercorticism): Long-time use of TARPEYO can cause you to have signs and symptoms of too much cortisol, a stress hormone in your blood. Tell your healthcare provider if you have any of the following signs and symptoms of hypercorticism: acne, bruise easily, rounding of your face (moon face), ankle swelling, thicker or more hair on your body and face, a fatty pad or hump between your shoulders (buffalo hump), or pink or purple stretch marks on the skin of your abdomen, thighs, breasts, or arms
  • Adrenal suppression: When TARPEYO is taken for a long period of time (chronic use), adrenal suppression can happen. This is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal suppression include tiredness, weakness, nausea and vomiting, and low blood pressure. Tell your healthcare provider if you are under stress or have any symptoms of adrenal suppression during treatment with TARPEYO
  • Risk of immunosuppression: TARPEYO weakens your immune system. Taking medicines that weaken your immune system makes you more likely to get infections. Avoid contact with people who have contagious diseases, such as chickenpox or measles, during treatment with TARPEYO. Tell your healthcare provider right away if you come in contact with anyone who has chickenpox or measles. Consult with your healthcare provider regarding appropriate vaccination scheduling
  • Tell your healthcare provider if you develop any symptoms of infection during treatment with TARPEYO, including fever, feeling tired, chills, aches, pain, and nausea and vomiting

The most common side effects of TARPEYO include:

  • swelling of the lower legs, ankles, and feet
  • high blood pressure
  • muscle spasms
  • acne
  • headache
  • upper respiratory tract infection
  • swelling of the face
  • weight increase
  • indigestion
  • irritation or inflammation of the skin
  • joint pain
  • increased white blood cell count

These are not all the possible side effects of TARPEYO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information.